A new review notes that recent epidemiological and clinical studies have built a consensus that ginger has beneficial effects against obesity, diabetes, cardiovascular diseases, and related disorders–more commonly referred to as metabolic syndrome.
Ginger has these effects by regulating fat metabolism, suppressing carbohydrate digestion, modulating insulin secretion and response, inhibiting oxidative stress, and lowering blood pressure and cholesterol. Studies have also identified the mechanisms and cellular molecules involved.
In recent years, metabolic syndromes (MetSs), including diabetes mellitus, dyslipidemia, and cardiovascular diseases, have become a common health problem in both developed and developing countries.
Accumulating data have suggested that traditional herbs might be able to provide a wide range of remedies in prevention and treatment of MetSs. Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been documented to ameliorate hyperlipidemia, hyperglycemia, oxidative stress, and inflammation. These beneficial effects are mediated by transcription factors, such as peroxisome proliferator–activated receptors, adenosine monophosphate–activated protein kinase, and nuclear factor κB.
This review focuses on recent findings regarding the beneficial effects of ginger on obesity and related complications in MetS and discusses its potential mechanisms of action. This review provides guidance for further applications of ginger for personalized nutrition and medicine.
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